Role of thymosin beta4 in tumor metastasis and angiogenesis.
AuthorsCha HJ, Jeong MJ, Kleinman HK,
JournalJ Natl Cancer Inst
PubMed ID14625258
'BACKGROUND: Expression of the small peptide thymosin beta4 is associated with angiogenesis induction, accelerated wound healing, and the metastatic potential of tumor cells. However, little is known about the mechanism(s) by which thymosin beta4 promotes metastasis. METHODS: Northern blot analysis and immunohistochemistry were used to examine thymosin beta4 expression in ... More
Metformin prevents the development of chronic heart failure in the SHHF rat model.
AuthorsCittadini A, Napoli R, Monti MG, Rea D, Longobardi S, Netti PA, Walser M, Samà M, Aimaretti G, Isgaard J, Saccà L,
JournalDiabetes
PubMed ID22344560
Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs (metformin and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF). Thirty SHHF rats were randomized into three treatment groups as follows: 1) metformin ... More