Kruppel-like factors regulate the LAMA1 gene encoding the laminin alpha1 chain.
AuthorsPiccinni SA, Bolcato-Bellemin AL, Klein A, Yang VW, Kedinger M, Simon-Assmann P, Lefebvre O,
JournalJ Biol Chem
PubMed ID14634001
'Laminin-1 (alpha1 beta1 gamma1), a basement membrane (BM) constituent, has been associated with differentiation processes but also with malignant progression. In the intestinal tissue, the alpha1 chain is expressed and secreted in the subepithelial BM during the developmental period; in the adult rodent tissue, it is restricted to the BM ... More
Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.
Authors Wang Yong; Lyu Yi Lisa; Wang James C;
JournalProc Natl Acad Sci U S A
PubMed ID12209014
The human TOP3alpha gene encoding DNA topoisomerase IIIalpha (hTop3alpha) has two potential start codons for the synthesis of proteins 1,001 and 976 aa residues in length. The sequence of the N-terminal region of the 1,001-residue form resembles signal peptide sequences for mitochondrial import, and fluorescence microscopy shows that the addition ... More