Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy.
Authors Lang Rosalyn; Gomes Aldrin V; Zhao Jiaju; Housmans Philippe R; Miller Todd; Potter James D;
JournalJ Biol Chem
PubMed ID11801593
'Familial hypertrophic cardiomyopathy has been associated with several mutations in the gene encoding human cardiac troponin I (HCTnI). A missense mutation in the inhibitory region of TnI replaces an arginine residue at position 145 with a glycine and cosegregates with the disease. Results from several assays indicate that the inhibitory ... More
Soybean ENOD40 encodes two peptides that bind to sucrose synthase.
ENOD40 is expressed at an early stage in root nodule organogenesis in legumes. Identification of ENOD40 homologs in nonleguminous plants suggests that this gene may have a more general biological function. In vitro translation of soybean ENOD40 mRNA in wheat germ extracts revealed that the conserved nucleotide sequence at the ... More