Cytokine markers as predictors of type of respiratory infection in patients during the influenza season.
AuthorsHaran JP, Buglione-Corbett R, Lu S,
JournalAm J Emerg Med
PubMed ID23481156
'The objective of this study is to characterize the cytokine response among patients presenting with an influenza-like illness who are infected with the influenza virus, a bacterial pneumonia, or another viral infection. We hypothesize that there are differences in proinflammatory and anti-inflammatory cytokines in relation to cytokines associated with the ... More
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
AuthorsIyer A, Zurolo E, Prabowo A, Fluiter K, Spliet WG, van Rijen PC, Gorter JA, Aronica E,
JournalPLoS One
PubMed ID23028621
Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of inflammation in human neurological disorders. In the present study we investigated the role of miR-146a, a key regulator of the innate immune response, in the modulation of astrocyte-mediated inflammation. Using Taqman PCR and in situ hybridization, we studied ... More
Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity.
AuthorsMajji S, Wijayalath W, Shashikumar S, Brumeanu TD, Casares S
JournalMalar J
PubMed ID29540197
'Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2R?cKO.NOD) mice reconstitute a functional human-immune-system and sustain the complete life cycle of Plasmodium falciparum. Herein, the DRAGA mice were investigated for immune responses following immunization with live P. ... More