Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.
AuthorsMelkus MW, Estes JD, Padgett-Thomas A, Gatlin J, Denton PW, Othieno FA, Wege AK, Haase AT, Garcia JV,
JournalNat Med
PubMed ID17057712
'Here we show that transplantation of autologous human hematopoietic fetal liver CD34+ cells into NOD/SCID mice previously implanted with human fetal thymic and liver tissues results in long-term, systemic human T-cell homeostasis. In addition, these mice show systemic repopulation with human B cells, monocytes and macrophages, and dendritic cells (DCs). ... More
Joint analysis of multiple biomarkers for identifying type 2 diabetes in middle-aged and older Chinese: a cross-sectional study.
AuthorsWu H, Yu Z, Qi Q, Li H, Sun Q, Lin X
JournalBMJ Open
PubMed ID22021786
'Identifying individuals with high risk of type 2 diabetes is important. To evaluate discriminatory ability of multiple biomarkers for type 2 diabetes in a Chinese population.' ... More
Propolis with high flavonoid content collected by honey bees from Acacia paradoxa.
AuthorsTran VH, Duke RK, Abu-Mellal A, Duke CC,
JournalPhytochemistry
PubMed ID22784552
'Honey bees, Apis mellifera var ligustica, on Kangaroo Island, Australia, were found to collect propolis from the sticky exudate on the stem shoots and seed pods of an Australian endemic plant, Acacia paradoxa. Extracts of the plant stem shoots and seed pods, the propolis carried on the legs of bees ... More
Role of eotaxin-1 signaling in ovarian cancer.
AuthorsLevina V, Nolen BM, Marrangoni AM, Cheng P, Marks JR, Szczepanski MJ, Szajnik ME, Gorelik E, Lokshin AE,
JournalClin Cancer Res
PubMed ID19351767
'Tumor cell growth and migration can be directly regulated by chemokines. In the present study, the association of CCL11 with ovarian cancer has been investigated. Experimental Design and Circulating levels of CCL11 in sera of patients with ovarian cancer were significantly lower than those in healthy women or women with ... More
Chemokines are associated with delirium after cardiac surgery.
AuthorsRudolph JL, Ramlawi B, Kuchel GA, McElhaney JE, Xie D, Sellke FW, Khabbaz K, Levkoff SE, Marcantonio ER
JournalJ Gerontol A Biol Sci Med Sci
PubMed ID18314455
Delirium has been hypothesized to be a central nervous system response to systemic inflammation during a state of blood-brain barrier compromise. The purpose of this study was to compare postoperative changes in groups of inflammatory markers in persons who developed delirium following cardiac surgery and matched controls without delirium. ... More
Antagonistic effects of aspirin and folic acid on inflammation markers and subsequent risk of recurrent colorectal adenomas.
AuthorsHo GY, Xue X, Cushman M, McKeown-Eyssen G, Sandler RS, Ahnen DJ, Barry EL, Saibil F, Bresalier RS, Rohan TE, Baron JA
JournalJ Natl Cancer Inst
PubMed ID19822838
The Aspirin/Folate Polyp Prevention Trial found that aspirin, but not folic acid, reduced recurrence of colorectal adenomas. This study examined whether treatment effects on inflammation markers explained the trial results. The trial had a factorial design with three aspirin (placebo, 81, and 325 mg/d) and two folic acid (placebo and ... More