Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma.
AuthorsBrooks HD, Glisson BS, Bekele BN, Johnson FM, Ginsberg LE, El-Naggar A, Culotta KS, Takebe N, Wright J, Tran HT, Papadimitrakopoulou VA,
JournalCancer
PubMed ID21523723
'Treatment options for patients with advanced head and neck squamous cell carcinoma (HNSCC) are scarce. This phase 2 study was conducted to evaluate the safety, tolerability, pharmacokinetics, and efficacy of dasatinib in this setting. Patients with recurrent and/or metastatic HNSCC after platinum-based therapy were treated with dasatinib either orally or ... More
Reliability of tumor markers, chemokines, and metastasis-related molecules in serum.
AuthorsLinkov F, Gu Y, Arslan AA, Liu M, Shore RE, Velikokhatnaya L, Koenig KL, Toniolo P, Marrangoni A, Yurkovetsky Z, Zeleniuch-Jacquotte A, Lokshin AE
JournalEur Cytokine Netw
PubMed ID19318317
There is a growing interest in the role that cancer biomarkers, metastasis-related molecules, and chemokines may play in the development and progression of various cancers. However, few studies have addressed the reliability of such biomarkers in healthy individuals over time. The objective of this study was to investigate the temporal ... More