Intra-thymic/splenic engraftment of human T cells in HLA-DR1 transgenic NOD/scid mice.
AuthorsCamacho RE, Wnek R, Shah K, Zaller DM, O'Reilly RJ, Collins N, Fitzgerald-Bocarsly P, Koo GC,
JournalCell Immunol
PubMed ID15922719
A HLA-DR1 transgenic mouse (NOD/scid-DR1) was derived by breeding the existing B10.M/J-[Tg]DR1 mouse with the NOD/scid mouse. The intention was to enhance engraftment of human T cells by providing human class II elements in the tissues. Thymus and spleen fragments from adult NOD/scid-DR1 mice were transplanted under the syngeneic kidney ... More