Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver.
AuthorsHolt AP, Haughton EL, Lalor PF, Filer A, Buckley CD, Adams DH,
JournalGastroenterology
PubMed ID19010327
'The recruitment of lymphocytes to tissues via endothelium has been studied extensively but less is known about the signals that direct migration and positioning within tissues. Liver myofibroblasts associate with lymphocytes in hepatitis and are positioned below the sinusoidal endothelium, through which lymphocytes are recruited to the liver. We investigated ... More
CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.
AuthorsZhang J, Sokal I, Peskind ER, Quinn JF, Jankovic J, Kenney C, Chung KA, Millard SP, Nutt JG, Montine TJ,
JournalAm J Clin Pathol
PubMed ID18343778
The therapeutic imperative for Alzheimer disease (AD) and Parkinson disease (PD) calls for discovery and validation of biomarkers. Increased cerebrospinal fluid (CSF) tau and decreased amyloid (A) beta42 have been validated as biomarkers of AD. In contrast, there is no validated CSF biomarker for PD. We validated our proteomics-discovered multianalyte ... More