Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation.
AuthorsWenink MH, Santegoets KC, Platt AM, van den Berg WB, van Riel PL, Garside P, Radstake TR, McInnes IB,
JournalAnn Rheum Dis
PubMed ID21908454
'We investigated whether Abatacept might reduce proinflammatory cytokine production by macrophages upon contact with cytokine activated T cells and/or stimulation with TLR ligands. Macrophages and cytokine stimulated T cells (Tck) were added together in the presence of Abatacept or a control Ig, with or without TLR ligands. The production of ... More
Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana.
AuthorsShapiro RL, Lockman S, Kim S, Smeaton L, Rahkola JT, Thior I, Wester C, Moffat C, Arimi P, Ndase P, Asmelash A, Stevens L, Montano M, Makhema J, Essex M, Janoff EN,
JournalJ Infect Dis
PubMed ID17624842
'Infants of human immunodeficiency virus (HIV)-infected women have high mortality, but the immunologic integrity and protection afforded by the breast milk of HIV-infected women is unknown. We determined morbidity and mortality by 24 months among breast-fed infants of 588 HIV-infected and 137 HIV-uninfected women followed-up in a clinical trial in ... More
Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis.
AuthorsVandooren B, Noordenbos T, Ambarus C, Krausz S, Cantaert T, Yeremenko N, Boumans M, Lutter R, Tak PP, Baeten D
JournalArthritis Rheum
PubMed ID19333931
'Peripheral spondylarthritis (SpA) is characterized by macrophages that express CD163, a marker of alternative activation (M2). The purpose of this study was to assess whether this differential infiltration with macrophage subsets was associated with a different local inflammatory milieu in SpA as compared with rheumatoid arthritis (RA).' ... More
Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function.
AuthorsTrepiakas R, Pedersen AE, Met O, Svane IM,
JournalVaccine
PubMed ID19428835
Monocyte-derived dendritic cells (DCs) are used as adjuvant cells in cancer immunotherapy and have shown promising results. In order to obtain full functional capacity, these DCs need to be maturated, and the current ... More
Reproducibility of serum cytokines and growth factors.
AuthorsGu Y, Zeleniuch-Jacquotte A, Linkov F, Koenig KL, Liu M, Velikokhatnaya L, Shore RE, Marrangoni A, Toniolo P, Lokshin AE, Arslan AA
JournalCytokine
PubMed ID19058974
In most studies, circulating biomarkers are usually assessed from a single sample, assuming that this single measurement represents the long-term biomarker status of the individual. Such an assumption is rarely tested although it may not be valid for all biomarkers. The objective of this study was to investigate the temporal ... More
Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy.
AuthorsEllertsen LK, Storla DG, Diep LM, Brokstad KA, Wiker HG, Hetland G
JournalBMC Infect Dis
PubMed ID19558655
It is still a matter of debate whether there is an association between infection with Mycobacterium tuberculosis (M. tuberculosis) and allergy. Previously, we have shown higher levels of specific IgE to different inhalant allergens and total IgE in tuberculosis (TB) patients compared to controls. The objectives of this study were ... More
Phase I Dendritic Cell p53 Peptide Vaccine for Head and Neck Cancer.
AuthorsSchuler PJ, Harasymczuk M, Visus C, Deleo A, Trivedi S, Lei Y, Argiris A, Gooding W, Butterfield LH, Whiteside TL, Ferris RL,
Journal
PubMed ID24583792
Background: p53 accumulation in head and neck squamous cell carcinoma (HNSCC) cells creates a targetable tumor antigen. Adjuvant dendritic cell (DC)-based vaccination against p53 was tested in a phase I clinical trial. Experimental Methods: Monocyte-derived DC from 16 patients were loaded with two modified HLA-class I p53 peptides (Arm 1), ... More
Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke.
AuthorsRodriguez-Mercado R, Ford GD, Xu Z, Kraiselburd EN, Martinez MI, Eterovic VA, Colon E, Rodriguez IV, Portilla P, Ferchmin PA, Gierbolini L, Rodriguez-Carrasquillo M, Powell MD, Pulliam JV, McCraw CO, Gates A, Ford BD,
JournalComp Med
PubMed ID23114047
The goal of this study was to characterize acute neuronal injury in a novel nonhuman primate (NHP) ischemic stroke model by using multiple outcome measures. Silk sutures were inserted into the M1 segment of the middle cerebral artery of rhesus macaques to achieve permanent occlusion of the vessel. The sutures ... More
Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders.
AuthorsAshwood P, Schauer J, Pessah IN, Van de Water J
JournalJ Neuroimmunol
PubMed ID19211157
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders that manifest in childhood. Immune dysregulation and autoimmune reactivity may contribute to the etiology of ASD and are likely the result of both genetic and environmental susceptibilities. A common environmental contaminant, 2,2',4,4'-tetrabrominated biphenyl (BDE-47), was tested for differential effects on the immune ... More