'Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets ... More
Respiratory Tract Epithelial Cells Express Retinaldehyde Dehydrogenase ALDH1A and Enhance IgA Production by Stimulated B Cells in the Presence of Vitamin A.
AuthorsRudraraju R, Jones BG, Surman SL, Sealy RE, Thomas PG, Hurwitz JL,
Journal
PubMed ID24466150
'Morbidity and mortality due to viral infections are major health concerns, particularly when individuals are vitamin A deficient. Vitamin A deficiency significantly impairs mucosal IgA, a first line of defense against virus at its point of entry. Previous reports have suggested that CD11c(Hi) dendritic cells (DCs) of the gastrointestinal tract ... More
Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis.
AuthorsHarris VK, Faroqui R, Vyshkina T, Sadiq SA,
JournalStem Cells Transl Med
PubMed ID23197858
'Bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) are a potential therapeutic source of cells that have been shown to be efficacious in a preclinical model of multiple sclerosis (MS). To examine the feasibility of using MSC-NPs as an autologous source of cells to promote central nervous system (CNS) repair ... More
B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6- and TNF-a-producing B-cell subsets in healthy humans.
AuthorsLangkjær A, Kristensen B, Hansen BE, Schultz H, Hegedüs L, Nielsen CH,
JournalClin Immunol
PubMed ID22885146
Human B cells are able to secrete IL-10 after stimulation with mitogens, but their ability to produce IL-10 and regulate T-cell responses after stimulation with self-antigens is unclear. We co-cultured thyroglobulin-pulsed B cells from healthy donors with autologous T cells and observed production of IL-10 and TGF-ß, in addition to ... More
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered to be tumour promoting. In contrast, the exact nature of protective antitumour immunity remains obscure. Here, we quantify locally secreted cytokines during primary immune responses against myeloma and ... More
IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities.
AuthorsHo MY, Leu SJ, Sun GH, Tao MH, Tang SJ, Sun KH,
JournalJ Immunol
PubMed ID19841177
Gene transfer of IL-27 to tumor cells has been proven to inhibit tumor growth in vivo by antiproliferation, antiangiogenesis, and stimulation of immunoprotection. To investigate the nonimmune mechanism of IL-27 that suppresses lung cancer growth, we have established a single-chain IL-27-transduced murine Lewis lung carcinoma (LLC-1) cell line (LLC-1/scIL-27) to ... More
BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.
AuthorsMurray LA, Hackett TL, Warner SM, Shaheen F, Argentieri RL, Dudas P, Farrell FX, Knight DA,
JournalPLoS One
PubMed ID19112509
Bone morphogenic protein (BMP)-7 is a member of the BMP family which are structurally and functionally related, and part of the TGFbeta super family of growth factors. BMP-7 has been reported to inhibit renal fibrosis and TGFbeta1-induced epithelial-mesenchymal transition (EMT), in part through negative interactions with TGFbeta1 induced Smad 2/3 ... More