Enhanced lung disease and Th2 response following human metapneumovirus infection in mice immunized with the inactivated virus.
AuthorsHamelin ME, Couture C, Sackett MK, Boivin G
JournalJ Gen Virol
PubMed ID18024909
'Human metapneumovirus (hMPV) is a paramyxovirus that causes acute respiratory-tract infections in humans. The histopathological and immunological responses to hMPV infection in BALB/c mice immunized with inactivated hMPV were characterized. Animals were immunized intraperitoneally with PBS, supernatant from non-infected LLC-MK2 cells and from heat-inactivated influenza A- or hMPV-infected cells, all ... More
PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo.
AuthorsBerdnikovs S, Pavlov VI, Abdala-Valencia H, McCary CA, Klumpp DJ, Tremblay ML, Cook-Mills JM
JournalJ Immunol
PubMed ID22156494
'It is reported that PTP1B limits cytokine signaling in vitro. However, PTP1B''s function during inflammation in vivo is not known. In this report, we determined whether PTP1B deficiency affects allergic inflammation in vivo. Briefly, lungs of OVA-challenged PTP1B(-/-) mice had elevated numbers of eosinophils and eosinophil progenitors at 6 h ... More
Dexamethasone/1alpha-25-dihydroxyvitamin D3-treated dendritic cells suppress colitis in the SCID T-cell transfer model.
AuthorsPedersen AE, Schmidt EG, Gad M, Poulsen SS, Claesson MH,
JournalImmunology
PubMed ID19019085
'Autoantigen-presenting immunomodulatory dendritic cells (DCs) that are used for adoptive transfer have been shown to be a promising therapy for a number of autoimmune diseases. We have previously demonstrated that enteroantigen-pulsed DCs treated with interleukin-10 (IL-10) can partly protect severe combined immunodeficient (SCID) mice adoptively transferred with CD4+ CD25(-) T ... More
A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein.
AuthorsHerrera E, Barcenas P, Hernández R, Méndez A, Pérez-Ishiwara G, Barrón B,
JournalVirol J
PubMed ID20727167
The hemagglutinin-neuraminidase (HN) protein is the major antigenic determinant of the Mumps virus (MuV) and plays an important role in the viral infectious cycle through its hemagglutination/hemadsorption (HA/HD) and neuraminidase (NA) activities. Objective: analyze the biological and immunological properties of a polypeptide derived from a highly conserved region of the ... More
Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice.
AuthorsComstock SS, Gershwin LJ, Teuber SS,
JournalAnn N Y Acad Sci
PubMed ID20388137
English walnuts are implicated in severe, IgE-mediated food allergy in humans. We sought to determine if polyphenolic compounds extracted from the edible nut could promote IgE production to a coadministered allergen. BALB/c mice were sensitized to ovalbumin (OVA) with or without alum (AL) or polyphenolic-enriched extract via intraperitoneal injection. Serum ... More
Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis.
AuthorsKuhlmann T, Remington L, Cognet I, Bourbonniere L, Zehntner S, Guilhot F, Herman A, Guay-Giroux A, Antel JP, Owens T, Gauchat JF,
JournalAm J Pathol
PubMed ID16877358
Multiple sclerosis is an inflammatory disease of the central nervous system that leads to loss of myelin and oligodendrocytes and damage to axons. We show that daily administration (days 8 to 24) of murine ciliary neurotrophic factor (CNTF), a neurotrophic factor that has been described as a survival and differentiation ... More
Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells.
CD73-derived adenosine acts as potent inhibitor of inflammation, and regulatory T cells (Treg) have been shown to express CD73 as a novel marker. This study explored the role of endogenously formed adenosine in modulating NF-?B activity and cytokine/chemokine release from murine Treg and effector T cells (Teff) including key enzymes/purinergic ... More
Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia.
AuthorsMack CL, Tucker RM, Sokol RJ, Kotzin BL,
JournalClin Immunol
PubMed ID15885644
Biliary atresia (BA) is an inflammatory cholangiopathy of infancy. A proposed mechanism regarding the pathogenesis of BA is that of a virus-induced, immune-mediated injury to bile ducts. The rotavirus (RRV)-induced murine model of BA was utilized to determine the hepatic inflammatory response related to ductal obstruction and if the immune ... More
Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of a-tocopherol and ?-tocopherol's effects.
AuthorsMcCary CA, Abdala-Valencia H, Berdnikovs S, Cook-Mills JM
JournalJ Immunol
PubMed ID21317387
We have reported that supplemental doses of the a- and ?-tocopherol isoforms of vitamin E decrease and increase, respectively, allergic lung inflammation. We have now assessed whether these effects of tocopherols are reversible. For these studies, mice were treated with Ag and supplemental tocopherols in a first phase of treatment ... More