Within-lifetime trade-offs but evolutionary freedom for hormonal and immunological traits: evidence from mice bred for high voluntary exercise.
AuthorsDowns CJ, Schutz H, Meek TH, Dlugosz EM, Acosta W, de Wolski KS, Malisch JL, Hayes JP, Garland T
JournalJ Exp Biol
PubMed ID22539732
Chronic increases in circulating corticosterone (CORT) generally suppress immune function, but it is not known whether evolved increases necessarily have similar adverse effects. Moreover, the evolution of immune function might be constrained by the sharing of signaling molecules, such as CORT, across numerous physiological systems. Laboratory house mice (Mus domesticus ... More