Toll-like receptor 9 expression in murine and human adrenal glands and possible implications during inflammation.
AuthorsTran N, Koch A, Berkels R, Boehm O, Zacharowski PA, Baumgarten G, Knuefermann P, Schott M, Kanczkowski W, Bornstein SR, Lightman SL, Zacharowski K
JournalJ Clin Endocrinol Metab
PubMed ID17473064
'Sepsis is a leading cause of death in the Western world and can be associated with failure of the hypothalamic-pituitary-adrenal axis. A coordinated response of the adrenal and immune system is of vital importance for survival during sepsis. Within the immune response, Toll-like receptors (TLRs) play a crucial role by ... More
Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice.
AuthorsCai P, Khan MF, Kaphalia BS, Ansari GA,
JournalJ Immunotoxicol
PubMed ID18958679
An epidemic of a multi-systemic disease, known as the toxic oil syndrome (TOS), was caused by consumption of edible oil denatured with 2% aniline. Oleic acid anilide (OAA) has been suggested as one of the most likely etiologic agents responsible for TOS based upon its presence in high quantities in ... More
Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells.
Abatacept modulates CD28-mediated T cell costimulation and is efficacious in the treatment of rheumatoid arthritis (RA). Its mechanism of action has not been fully elucidated but will likely reveal critical pathologic pathways in RA. We show that abatacept substantially modulated Ag-specific T and B cell responses in vivo. Ag-specific T ... More
Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice.
AuthorsFonseca-Aten M, Ríos AM, Mejías A, Chávez-Bueno S, Katz K, Gómez AM, McCracken GH, Hardy RD
JournalAm J Respir Cell Mol Biol
PubMed ID15626776
Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20-40% of individuals. The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to ... More
Intranasal interleukin-12 therapy inhibits Mycoplasma pneumoniae clearance and sustains airway obstruction in murine pneumonia.
AuthorsSalvatore CM, Fonseca-Aten M, Katz-Gaynor K, Gomez AM, Hardy RD
JournalInfect Immun
PubMed ID18039833
Mycoplasma pneumoniae is a leading cause of pneumonia and is associated with asthma. Evidence links M. pneumoniae respiratory disease severity with interleukin-12 (IL-12) concentrations in respiratory secretions. We evaluated the effects of IL-12 therapy on microbiologic, inflammatory, and pulmonary function indices of M. pneumoniae pneumonia in mice. BALB/c mice were ... More
Ascaris suum-derived products suppress mucosal allergic inflammation in an interleukin-10-independent manner via interference with dendritic cell function.
AuthorsMcConchie BW, Norris HH, Bundoc VG, Trivedi S, Boesen A, Urban JF, Keane-Myers AM
JournalInfect Immun
PubMed ID16966410
We have previously demonstrated that protection from allergic inflammation by Ascaris suum infection was characterized by a global increase in interleukin-10 (IL-10) and the development of protective CD4(+)/CD25(+) T cells (L. Schopf, S. Luccioli, V. Bundoc, P. Justice, C. C. Chan, B. J. Wetzel, H. H. Norris, J. F. Urban, ... More
Oleanolic Acid, a plant triterpenoid, significantly improves survival and function of islet allograft.
AuthorsNataraju A, Saini D, Ramachandran S, Benshoff N, Liu W, Chapman W, Mohanakumar T
JournalTransplantation
PubMed ID19855244
BACKGROUND.: Oleanolic acid (OA) is a ubiquitous triterpenoid, with potent antioxidant and anti-inflammatory properties. Here, we tested whether these combined properties of OA can prevent nonimmunologic primary nonfunctioning and immunologic phenomena ascribed to graft rejection hence prolong islet allograft survival. METHODS.: Islet transplants were performed under kidney capsule of streptozotocin-induced ... More
Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis.
Epidemiological evidence indicates that environmental air pollutants are positively associated with the development of chronic vascular disease; however, the mechanisms involved have not been fully elucidated. In the present study we examined molecular pathways associated with chronic vascular disease in atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice, including markers of vascular remodeling ... More