Enhanced lung disease and Th2 response following human metapneumovirus infection in mice immunized with the inactivated virus.
AuthorsHamelin ME, Couture C, Sackett MK, Boivin G
JournalJ Gen Virol
PubMed ID18024909
'Human metapneumovirus (hMPV) is a paramyxovirus that causes acute respiratory-tract infections in humans. The histopathological and immunological responses to hMPV infection in BALB/c mice immunized with inactivated hMPV were characterized. Animals were immunized intraperitoneally with PBS, supernatant from non-infected LLC-MK2 cells and from heat-inactivated influenza A- or hMPV-infected cells, all ... More
Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice.
AuthorsCai P, Khan MF, Kaphalia BS, Ansari GA,
JournalJ Immunotoxicol
PubMed ID18958679
An epidemic of a multi-systemic disease, known as the toxic oil syndrome (TOS), was caused by consumption of edible oil denatured with 2% aniline. Oleic acid anilide (OAA) has been suggested as one of the most likely etiologic agents responsible for TOS based upon its presence in high quantities in ... More
Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells.
Abatacept modulates CD28-mediated T cell costimulation and is efficacious in the treatment of rheumatoid arthritis (RA). Its mechanism of action has not been fully elucidated but will likely reveal critical pathologic pathways in RA. We show that abatacept substantially modulated Ag-specific T and B cell responses in vivo. Ag-specific T ... More
Ascaris suum-derived products suppress mucosal allergic inflammation in an interleukin-10-independent manner via interference with dendritic cell function.
AuthorsMcConchie BW, Norris HH, Bundoc VG, Trivedi S, Boesen A, Urban JF, Keane-Myers AM
JournalInfect Immun
PubMed ID16966410
We have previously demonstrated that protection from allergic inflammation by Ascaris suum infection was characterized by a global increase in interleukin-10 (IL-10) and the development of protective CD4(+)/CD25(+) T cells (L. Schopf, S. Luccioli, V. Bundoc, P. Justice, C. C. Chan, B. J. Wetzel, H. H. Norris, J. F. Urban, ... More
Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of a-tocopherol and ?-tocopherol's effects.
AuthorsMcCary CA, Abdala-Valencia H, Berdnikovs S, Cook-Mills JM
JournalJ Immunol
PubMed ID21317387
We have reported that supplemental doses of the a- and ?-tocopherol isoforms of vitamin E decrease and increase, respectively, allergic lung inflammation. We have now assessed whether these effects of tocopherols are reversible. For these studies, mice were treated with Ag and supplemental tocopherols in a first phase of treatment ... More