Intranasal administration of poly(I:C) and LPS in BALB/c mice induces airway hyperresponsiveness and inflammation via different pathways.
AuthorsStarkhammar M, Kumlien Georén S, Swedin L, Dahlén SE, Adner M, Cardell LO,
JournalPLoS One
PubMed ID22355412
'Bacterial and viral infections are known to promote airway hyperresponsiveness (AHR) in asthmatic patients. The mechanism behind this reaction is poorly understood, but pattern recognizing Toll-like receptors (TLRs) have recently been suggested to play a role. To explore the relation between infection-induced airway inflammation and the development of AHR, poly(I:C) ... More
The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.
AuthorsNibbs RJ, Gilchrist DS, King V, Ferra A, Forrow S, Hunter KD, Graham GJ,
JournalJ Clin Invest
PubMed ID17607362
'A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in shaping inflammatory responses. Recently, we and others have demonstrated that the atypical chemokine receptor D6 actively sequesters and destroys many of these proinflammatory CC chemokines. This is critical for effective resolution of inflammation ... More
Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages.
AuthorsShimizu S, Okuda N, Kato N, Rittling SR, Okawa A, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K, Asou Y,
JournalArthritis Rheum
PubMed ID20155835
To investigate the molecular mechanisms underlying particle-induced osteolysis, we focused on osteopontin (OPN), a cytokine and cell-attachment protein that is associated with macrophage chemoattractant and osteoclast activation. We compared OPN protein levels in human periprosthetic osteolysis tissues with those in osteoarthritis (OA) synovial tissues. To investigate the functions of OPN ... More
IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system.
AuthorsMillward JM, Caruso M, Campbell IL, Gauldie J, Owens T
JournalJ Immunol
PubMed ID17548656
Inflammation of the CNS, which occurs during multiple sclerosis and experimental autoimmune encephalomyelitis, is characterized by increased levels of IFN-gamma, a cytokine not normally expressed in the CNS. To investigate the role of IFN-gamma in CNS, we used intrathecal injection of a replication-defective adenovirus encoding murine IFN-gamma (AdIFNgamma) to IFN-gamma-deficient ... More