The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.
AuthorsNibbs RJ, Gilchrist DS, King V, Ferra A, Forrow S, Hunter KD, Graham GJ,
JournalJ Clin Invest
PubMed ID17607362
'A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in shaping inflammatory responses. Recently, we and others have demonstrated that the atypical chemokine receptor D6 actively sequesters and destroys many of these proinflammatory CC chemokines. This is critical for effective resolution of inflammation ... More
Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells.
Abatacept modulates CD28-mediated T cell costimulation and is efficacious in the treatment of rheumatoid arthritis (RA). Its mechanism of action has not been fully elucidated but will likely reveal critical pathologic pathways in RA. We show that abatacept substantially modulated Ag-specific T and B cell responses in vivo. Ag-specific T ... More
Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice.
AuthorsFonseca-Aten M, Ríos AM, Mejías A, Chávez-Bueno S, Katz K, Gómez AM, McCracken GH, Hardy RD
JournalAm J Respir Cell Mol Biol
PubMed ID15626776
Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20-40% of individuals. The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to ... More