Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice.
Authors Zinn Kurt R; Chaudhuri Tandra R; Krasnykh Victor N; Buchsbaum Donald J; Belousova Natalya; Grizzle William E; Curiel David T; Rogers Buck E;
JournalRadiology
PubMed ID11997547
PURPOSE: To compare two systems for assessing gene transfer to cancer cells and xenograft tumors with noninvasive gamma camera imaging. MATERIALS AND METHODS: A replication-incompetent adenovirus encoding the human type 2 somatostatin receptor (hSSTr2) and the herpes simplex virus thymidine kinase (TK) enzyme (Ad-hSSTr2-TK) was constructed. A-427 human lung cancer ... More