Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system.
AuthorsClive D, Johnson KO, Spector JF, Batson AG, Brown MM
JournalMutat Res
PubMed ID372791
The current status of the L5178Y/TK+/- leads to TK-/- mouse-lymphoma mutagenicity assay is described. Dose-survival-mutagenic response data are shown for 43 chemicals. Mutagenicity and cytotoxicity in the presence or absence of non-induced and/or Aroclor-induced rat-liver S-9 are compared for most of these chemicals, 25 of these for which usuable carcinogenicity ... More