Long-term exposure to CdTe quantum dots causes functional impairments in live cells.
AuthorsCho SJ, Maysinger D, Jain M, Röder B, Hackbarth S, Winnik FM
JournalLangmuir
PubMed ID17279683
'Several studies suggested that the cytotoxic effects of quantum dots (QDs) may be mediated by cadmium ions (Cd2+) released from the QDs cores. The objective of this work was to assess the intracellular Cd2+ concentration in human breast cancer MCF-7 cells treated with cadmium telluride (CdTe) and core/shell cadmium selenide/zinc ... More
Cadmium-mediated toxicity of lung epithelia is enhanced through NF-?B-mediated transcriptional activation of the human zinc transporter ZIP8.
AuthorsNapolitano JR, Liu MJ, Bao S, Crawford M, Nana-Sinkam P, Cormet-Boyaka E, Knoell DL,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID22345571
'Cadmium (Cd), a toxic heavy metal and carcinogen that is abundantly present in cigarette smoke, is a cause of smoking-induced lung disease. SLC39A8 (ZIP8), a zinc transporter, is a major portal for Cd uptake into cells. We have recently identified that ZIP8 expression is under the transcriptional control of the ... More