Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates.
AuthorsAyad WA, Locke D, Koreen IV, Harris AL
JournalJ Biol Chem
PubMed ID16601118
'Previous work has shown that channels formed by both connexin (Cx)26 and Cx32 (heteromeric Cx26/Cx32 hemichannels) are selectively permeable to cAMP and cGMP. To further investigate differential connexin channel permeability among second messengers, and the influence of connexin channel composition on the selectivity, the permeability of inositol phosphates with one ... More
Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions.
AuthorsBecker DL, Evans WH, Green CR, Warner A
JournalJ Cell Sci
PubMed ID7615666
'Gap junctions allow direct communication between cells without recourse to the extracellular space and have been widely implicated as important mediators of cell-cell signalling. They are constructed from the connexin proteins, which form a large family, and individual connexins show complex spatial and temporal variations in their expression patterns. Understanding ... More
Deprotonation dynamics and stokes shift of pyranine (HPTS).
AuthorsSpry DB, Goun A, Fayer MD,
JournalJ Phys Chem A
PubMed ID17214458
The short and intermediate time scale dynamics of the photoacid pyranine (1-hydroxy-3,6,8-pyrenetrisulfonic acid, commonly referred to as HPTS) are studied with visible pump-probe spectroscopy in various solvents to elucidate the nature of its proton-transfer kinetics in water. The observed time dependences of HPTS are compared with those of the methoxy ... More