Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.
AuthorsNagar S, Smith LE, Morgan WF
JournalCancer Res
PubMed ID12543783
'The detrimental effects associated with exposure to ionizing radiation have long been thought to result from the direct targeting of the nucleus leading to DNA damage; however, the emergence of concepts such as radiation-induced genomic instability and bystander effects have challenged this dogma. After cellular exposure to ionizing radiation, we ... More
Mechanisms of cell death associated with death-inducing factors from genomically unstable cell lines.
AuthorsNagar S, Smith LE, Morgan WF
JournalMutagenesis
PubMed ID14614192
'We recently described a unique non-targeted effect of ionizing radiation whereby growth medium from two clones of GM10115 cells exhibiting radiation-induced chromosomal instability was cytotoxic to parental GM10115 cells. We termed this the death-inducing effect (DIE). The goal of the present study was to determine how DIE killed cells. Our ... More
Ionizing radiation induces delayed hyperrecombination in Mammalian cells.
AuthorsHuang L, Grim S, Smith LE, Kim PM, Nickoloff JA, Goloubeva OG, Morgan WF
JournalMol Cell Biol
PubMed ID15143196
Exposure to ionizing radiation can result in delayed effects that can be detected in the progeny of an irradiated cell multiple generations after the initial exposure. These effects are described under the rubric of radiation-induced genomic instability and encompass multiple genotoxic endpoints. We have developed a green fluorescence protein (GFP)-based ... More
Angiotensin subtype 1 rReceptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor.
AuthorsThai H, Wollmuth J, Goldman S, Gaballa M
JournalJ Pharmacol Exp Ther
PubMed ID14560036
To determine whether angiotensin receptor blockade decreases vascular tone in heart failure by improving endothelial-dependent vasorelaxation and increasing nitric oxide (NO) bioavailability, we treated infarcted adult male Sprague-Dawley rats with candesartan for 7 days or 8 weeks (10 mg/kg/day in drinking water). Candesartan, at both time points, lowered left ventricular ... More
Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition.
Authors
JournalJ Hematol Oncol
PubMed ID32552902
The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.
Authors
JournalJ Clin Invest
PubMed ID35389887
Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms.
Authors
JournalNat Commun
PubMed ID34635673
Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages.
Authors
JournalNat Protoc
PubMed ID35121853
Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.
Authors
JournalNat Commun
PubMed ID34675215
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.
Authors
JournalNat Commun
PubMed ID32855420
A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis.
Authors
JournalCancer Res
PubMed ID33500248
A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models.
Authors
JournalClin Cancer Res
PubMed ID32273277
Effectiveness of porous silicon nanoparticle treatment at inhibiting the migration of a heterogeneous glioma cell population.
Authors
JournalJ Nanobiotechnology
PubMed ID33637089
A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer.