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Invitrogen
HSP90 beta Monoclonal Antibody (MBH90B)
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FIGURE: 1 / 6
HSP90 beta Antibody (MA1-10373) in ICC/IF
Immunofluorescence analysis of HSP90 beta was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with HSP90 beta Monoclonal Antibody (MBH90B) (Product # MA1-10373) at 1 µg/mL in 0.1% BSA, incubated at 4 degree Cels... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-10373
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MBH90B
Immunogen
Peptide corresponding to the EEVHHGEEEVEC sequence within N-terminal part of human Hsp90 (aa 3-14).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90 beta an ubiquitously expressed intracellular protein with calculated Mw of 83.3 kDa, however, migrating as a 90 kDa band under reducing SDS-PAGE conditions.
Target Information
Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Heat shock 84 kDa; heat shock 90 kDa protein; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; HSP; HSP 84; retinal degeneration slow protein; RP1-302G2.1; TSTA; Tumor-specific transplantation 84 kDa antigen
Gene Aliases: 90kDa; AL022974; C81438; Hsp84; Hsp84-1; Hsp90; HSP90AB1; HSPC3; HSPCB
UniProt ID: (Bovine) Q76LV1, (Mouse) P11499
Entrez Gene ID: (Bovine) 767874, (Mouse) 15516
double-stranded RNA binding
protein kinase regulator activity
protein kinase binding
heat shock protein binding
ubiquitin protein ligase binding
peptide binding
protein homodimerization activity
histone deacetylase binding
ATP-dependent protein binding
protein binding involved in protein folding
protein dimerization activity
tau protein binding
DNA polymerase binding
histone methyltransferase binding
nucleotide binding
UTP binding
CTP binding
protein binding
ATP binding
GTP binding
sulfonylurea receptor binding
kinase binding
MHC class II protein complex binding
dATP binding
ion channel binding
poly(A) RNA binding
unfolded protein binding
Hsp90 family chaperone
placenta development
telomere maintenance via telomerase
virion attachment to host cell
central nervous system neuron axonogenesis
establishment of cell polarity
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of phosphoprotein phosphatase activity
positive regulation of peptidyl-serine phosphorylation
negative regulation of apoptotic process
positive regulation of cell differentiation
axon extension
chaperone-mediated protein complex assembly
positive regulation of protein kinase B signaling
positive regulation of telomerase activity
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
negative regulation of cell cycle arrest
cellular response to interleukin-4
fibril organization
negative regulation of transforming growth factor beta activation
positive regulation of cyclin-dependent protein kinase activity
telomerase holoenzyme complex assembly
positive regulation of protein localization to cell surface
protein folding
response to stress
positive regulation of protein binding
positive regulation of protein import into nucleus, translocation
negative regulation of neuron apoptotic process
positive regulation of cell size
positive regulation of protein serine/threonine kinase activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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