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Invitrogen
TRPV1 Monoclonal Antibody (5G8A9G8)
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产品信息
MA1-18349
产品规格
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
5G8A9G8
抗原
Synthetic peptide corresponding to residues C-G(819) S L K P E D A E V F K D S M V P G E K(838) of rat VR1 conjugated to KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
2 mg/mL
规格
100 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
MA1-18349 detects capsaicin receptor from rat and guinea pig samples. MA1-18349 is expected to react with mouse samples based on sequence homology.
MA1-18349 has been successfully used in immunohistochemistry procedures.
The MA1-18349 immunogen is a synthetic peptide corresponding to residues C-G(819) S L K P E D A E V F K D S M V P G E K(838) of rat VR1, conjugated to KLH.
Reconstitute in 100µl of sterile water. Centrifuge to remove any insoluble material. After reconstitutuion keep aliquots at -20°C for a higher stability and at 4° with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
靶标信息
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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