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Invitrogen
BCL-XL Monoclonal Antibody (SPM165)
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产品信息
MA1-21260
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
SPM165
抗原
Synthetic peptide of Mouse Bcl xL amino acids 33-50 [NRTEAPEGTESEMETPSA]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
保存条件
4°C, do not freeze
运输条件
Wet ice
产品详细信息
MA1-21260 detects Bcl xL in Human and Mouse samples.
MA1-21260 has been successfully used in FACS, Immunofluorescence and Immunohistochemistry (Paraffin) procedures. Staining of formalin fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 minutes. A suggested positive control for this product is Hodgkin's lymphoma.
MA1-21260 immunogen corresponds to Synthetic peptide of Mouse Bcl xL amino acids 33-50 [NRTEAPEGTESEMETPSA].
靶标信息
BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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