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Invitrogen
CD34 Monoclonal Antibody (MEC14.7)
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Product Details
MA1-22646
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit
Published species
Human,
Mouse,
Rabbit
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MEC14.7
Immunogen
Mouse CD34
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects a neuraminidase sensitive epitope on endothelium in vivo, particullary on small vessels and neoformed capillaries and develpoing vascular structures in embryonal structures. Furthermore, the antibody reacts with hematopoietic progenitors particularly of myelomonocytic colony forming cells.
Target Information
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD34; CD34 antigen; CD34 sialomucin; cluster designation 34; glycoprotein expressed in lymphohematopoietic progenitor cells; Hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2; unnamed protein product
Gene Aliases: AU040960; CD34
UniProt ID: (Human) P28906, (Mouse) Q64314
Entrez Gene ID: (Human) 947, (Rabbit) 100343670, (Mouse) 12490
tissue homeostasis
endothelial cell proliferation
glomerular filtration
endothelium development
cell adhesion
cell-matrix adhesion
signal transduction
positive regulation of gene expression
negative regulation of gene expression
hemopoiesis
negative regulation of interleukin-2 production
mesangial cell-matrix adhesion
paracrine signaling
positive regulation of odontogenesis
positive regulation of angiogenesis
cell motility
leukocyte migration
transdifferentiation
vascular wound healing
hematopoietic stem cell proliferation
positive regulation of granulocyte colony-stimulating factor production
extracellular exosome assembly
glomerular endothelium development
stem cell proliferation
metanephric glomerular mesangial cell differentiation
cell-cell adhesion
positive regulation of vasculogenesis
regulation of blood pressure
single organismal cell-cell adhesion
negative regulation of blood coagulation
negative regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
negative regulation of nitric oxide biosynthetic process
positive regulation of transforming growth factor beta production
negative regulation of cellular response to heat
negative regulation of cellular response to hypoxia
negative regulation of interleukin-2 secretion
positive regulation of glial cell-derived neurotrophic factor secretion
negative regulation of neuron death
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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