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Invitrogen
CD61/ITGB5 Monoclonal Antibody (23C6)
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产品信息
MA1-23050
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
23C6
抗原
Cell suspension containing osteoclasts from osteoclastomas.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
MA1-23050 detects Integrin alpha V beta 3 in human samples.
MA1-23050 has been successfully used in FACS, immunohistochemistry (frozen), and immunoprecipitation procedures. For IHC, frozen sections should be acetone fixed. Postive Control: Tonsil 125/124kDa (reduced), 150kDa (non-reduced).
The MA1-23050 immunogen is a cell suspension containing osteoclasts from osteoclastomas.
靶标信息
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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