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Invitrogen
LAT Monoclonal Antibody (3.8)
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产品信息
MA1-24872
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3.8
抗原
Prokaryotic, partial, recombinant protein corresponding to a 120 residue region within the C-terminus of the LAT molecule.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
4°C, do not freeze
运输条件
Wet ice
产品详细信息
MA1-24872 detects LAT from human samples.
MA1-24872 has been successfully used in immunohistochemistry (paraffin) procedures.
The MA1-24872 immunogen is a prokaryotic, recombinant protein corresponding to a 120 residue region within the C-terminus of the LAT molecule.
For use of MA1-24872 in immunohistochemisty (paraffin) procedures, it is suggested the antibody is first incubated for 60 minutes at room temperature. Perform heat mediated antigen retrieval with 10 mM citrate buffer, pH 6.0 before commencing with IHC staining protocol.
靶标信息
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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