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Invitrogen
LRP5/LRP6 Monoclonal Antibody (1A12)
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产品信息
MA1-26494
产品规格
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1A12
抗原
Synthetic peptide corresponding to residues D T G T D R I E V T R of human LRP5 and LRP6.These residues are completely conserved between human and mouse.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
MA1-26494 detects LRP5 + LRP6 from human and mouse samples.
MA1-26494 has been successfully used in Western blot procedures.
The MA1-26494 immunogen is a synthetic peptide corresponding to residues D T G T D R I E V T R of human LRP5 and LRP6.These residues are completely conserved between human and mouse; and between LRP 5 and LRP 6.
靶标信息
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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