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Invitrogen
HLA-DR/DP/DQ Monoclonal Antibody (7.5.10.1)
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产品信息
MA1-35414
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
7.5.10.1
抗原
Human EVB-transformed B-cell line DR3/3
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
纯化类型
purified
保存液
PBS with 0.1% BSA
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody reacts with a monomorphic determinant on MHC class II, HLA-D region molecules. It detects the molecules of the HLA-DR, DP and DQ loci. It inhibits the mixed lymphocyte culture. It also reacts with MHC class II molecules of various animals and is a useful tool for studies with dogs. The antibody is useful for the identification of HLA-D positive molecules using either microcytotoxicity testing or immunofluorescence/immunoperoxidase procedures. Furthermore, it was found useful for studies on functional aspects of MHC class II molecules.
靶标信息
MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DR beta-5; DR2-beta-2; Dw2; FLJ75017; FLJ76359; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-D; HLA-DQ; HLA-DR; HLA-DRB1; Human leukocyte antigen DRB1; MHC Class 2; MHC class II; MHC class II antigen DPB1; MHC class II antigen DQB1; MHC class II antigen DRA; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC HLA-D; MHC II HLA; XXbac-BPG161M6.1
基因别名: HLA-DP1B; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DRA; HLA-DRA1; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5
Entrez Gene ID: (Human) 3115, (Human) 3119, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127
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