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Invitrogen
CD46 Monoclonal Antibody (M177)
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产品信息
MA1-40183
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
M177
抗原
purified MCP
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-40183 detects CD46 from human samples.
MA1-40183 has been successfully used in flow cytometry, immunoprecipitation, functional assays, immunohistochemistry (frozen) and Western blot applications.
The MA1-40183 immunogen is purified MCP.
Endotoxin <24 EU/mg.
Positive control: CD46 is expressed on every cell and tissue; Negative control: Erythrocytes.
靶标信息
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD46; Membrane cofactor protein; MGC26544; TLX; Trophoblast leukocyte common antigen
基因别名: CD46; MCP; MIC10
Entrez Gene ID: (Human) 4179
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