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Invitrogen
Phospho-AKT1 (Ser473) Monoclonal Antibody (104A282)
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产品信息
MA1-41002
产品规格
已发表种属
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
104A282
抗原
Synthetic phosphopeptide corresponding to the residues surrounding serine 473 of human AKT1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
MA1-41002 detects phospho-AKT1 (Ser473) in human and mouse samples. It is also predicted to react with chicken, zebrafish and frog samples.
MA1-41002 has been successfully used in Western blot, ICC and IF applications.
The MA1-41002 immunogen is a synthetic phosphopeptide corresponding to the residues surrounding serine 473 of human AKT1. The sequence in this region is identical in human, mouse, chicken, and frog.
靶标信息
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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