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Invitrogen
Phospho-Progesterone Receptor (Ser294) Monoclonal Antibody (608)
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图: 1 / 4
Phospho-Progesterone Receptor (Ser294) Antibody (MA1-414) in ICC/IF
Immunofluorescent analysis of Phosphorylated Progesterone Receptor using Phospho-Progesterone Receptor pSer294 Monoclonal Antibody (608) (Product # MA1-414) shows staining in MCF-7 Cells. Phospho-Progesterone Receptor pSer294 (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probe... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-414
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
608
抗原
Synthetic phosphopeptide corresponding to residues P(288) M A P G R S(p) P L A T T V(300) of human Progesterone Receptor.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
purified
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-414 detects phospho-progesterone receptor (pSer294) from human samples.
MA1-414 has been successfully used in Western blot, ELISA, immunohistochemistry, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects ~81 and ~116 kDa proteins representing phospho-progesterone receptor (pSer294) A and B from T47D cell extract.
The MA1-414 immunogen is a synthetic peptide corresponding to residues P(288) M A P G R S(p) P L A T T V(300) of human Progesterone Receptor
靶标信息
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Nuclear receptor subfamily 3 group C member 3; PR; Progesterone receptor
基因别名: NR3C3; PGR
Entrez Gene ID: (Human) 5241
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