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Invitrogen
Polyoma Virus Medium T Monoclonal Antibody (PyMT)
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FIGURE: 1 / 2
Polyoma Virus Medium T Antibody (MA1-46061) in ICC/IF
Immunofluorescence analysis of Polyoma Virus Medium T (green) in PyMT+ mammary tumor cells and mammary gland lymph node. Cells were stained with a Polyoma Virus Medium T Monoclonal Antibody (Product # MA1-46061) at a dilution of 1:500 overnight at 4C, and then incubated with secondary goat anti-rat IgG - Alexa Fluor 488 antibody (Product # A-11006) at a dilution of 1:500 for 1 hour. Data courtesy of Antib... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-46061
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Published species
Virus
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
PyMT
Immunogen
Polyoma Virus-transformed Wistar rat fibroblast cell line Py REWA5/T1A1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The Polyoma Virus Medium T (MT) antigen is associated with oncogenic processes in the virus's host cells. Polyoma Virus is a small, double-stranded DNA virus that primarily infects mice, leading either to lytic or abortive infections. The MT antigen plays a pivotal role in the virus's ability to induce tumors and transform cells. Structurally, the Polyoma Virus includes multiple T-antigens, with MT being one such protein that resembles growth factor receptors and mimics their function, thereby activating signaling pathways that lead to cell proliferation and transformation. The MT antigen has been extensively studied for its ability to initiate and sustain signaling pathways integral to cancer research, such as activating tyrosine kinases and phosphatidylinositol 3-kinases pathways, which are crucial for cell survival, growth, and division. The coding regions and structure of MT, derived from genetic, mRNA, peptide, and DNA analysis, have established its importance in polyoma's oncogenic activity, offering critical insights into molecular changes underlying tumorigenesis. Understanding the MT antigen's structure and function has significantly contributed to the study of viral mechanisms and cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MPyVgp2
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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