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Invitrogen
CD3e Monoclonal Antibody (CA17.2A12)
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产品信息
MA1-74203
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CA17.2A12
抗原
Affinity enriched TCR/CD3 membrane proteins isolated from thymocytes and the T cell line CLGL-90.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Dog CD3 antibody, clone CA17.2A12 recognizes the canine CD3 cell surface antigen, expressed by thymocytes and mature T lymphocytes.
靶标信息
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD3 epsilon; CD3 TCR complex; CD3d molecule, delta (CD3-TCR complex); CD3e; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3g molecule, gamma (CD3-TCR complex); FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell surface glycoprotein CD3 epsilon chain; T3/TCR complex
基因别名: CD3E
UniProt ID: (Dog) P27597
Entrez Gene ID: (Dog) 611571, (Dog) 479419, (Dog) 442981, (Dog) 489383
positive regulation of cell-matrix adhesion
adaptive immune response
positive regulation of T cell anergy
negative regulation of gene expression
dendrite development
cerebellum development
T cell costimulation
positive regulation of interferon-gamma production
positive regulation of interleukin-4 production
positive regulation of cell-cell adhesion mediated by integrin
negative thymic T cell selection
negative regulation of smoothened signaling pathway
positive regulation of alpha-beta T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
apoptotic signaling pathway
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