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Invitrogen
5-Methylcytidine Monoclonal Antibody (33D3)
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5-Methylcytidine Antibody (MA1-80331) in ChIP
Matrix MeDIP in human brain was performed using a monoclonal antibody targeting specifically 5mC methylated DNA (Product # MA1-80331). Differences in at ActB transcription start site (TSS) and H19 imprinting control region (ICR) for human brain are graphed by fraction of input. For all brain samples, P = <0.003 for ActB vs H19, and for H19 5mC vs IgG (two-tailed, two-sample t-Test). Data courtesy of Dr. Karol Bomsztyk laboratory.
产品信息
MA1-80331
应用
建议稀释比
已发表文章
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
33D3
抗原
Proprietary Immunogen.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti 5-methylcytidine antibody, clone 33D3 recognizes 5-methylcytidine, a modified base found in the DNA of plants and vertebrates.
靶标信息
Modified base 5-methyl cytidine (5-MeCyd) is found in DNA of plants and vertebrates. DNA methylation is a DNA modification process, which is involved in the control of gene expression. Reports suggest that in tumours, DNA is frequently globally hypomethylated compared to the DNA from normal tissue.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-Methyl-cytidine; C10H15N3O5
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