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Invitrogen

Protein APC Monoclonal Antibody (FE9)

View all (30) Protein APC antibodies

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Protein APC Monoclonal Antibody (FE9)

Product Details

MA1-91039

Applications
Tested Dilution
Publications

Western Blot (WB)

1-1.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

FE9

Immunogen

Immunogen used was a synthetic peptide corresponding to the N-terminal 35 amino acid residues of APC.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

50 µg

Purification

Protein G

Storage buffer

0.05M sodium phosphate, pH 7.5, with 0.2% gelatin

Contains

0.1% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1954862

Product Specific Information

Reacts with all full length and truncated APC proteins.

MA1-91039 has been successfully used in Western blot applications, where a band of approximately 312 kDa is predicted to be detected. Suggested positive controls for this product are HCT116 cells for p300 and SW480 cells for truncated APC (p147).

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli (APC); APC; APC, WNT signaling pathway regulator; deleted in polyposis 2.5; epididymis secretory sperm binding protein; FAP; FPC; multiple intestinal neoplasia; protein phosphatase 1, regulatory subunit 46; Unknown; unnamed protein product; WNT signaling pathway regulator

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Gene Aliases: BTPS2; CC1; DESMD; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC

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UniProt ID: (Human) P25054, (Rat) P70478

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Entrez Gene ID: (Human) 324, (Mouse) 11789, (Rat) 24205

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Function(s)
protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding ubiquitin protein ligase binding macromolecular complex binding gamma-catenin binding cadherin binding microtubule plus-end binding dynein complex binding protease binding identical protein binding
Process(es)
mitotic cytokinesis cell fate specification heart valve development endocardial cushion morphogenesis cellular response to DNA damage stimulus negative regulation of microtubule depolymerization mitotic spindle assembly checkpoint cell adhesion pattern specification process nervous system development negative regulation of cell proliferation insulin receptor signaling pathway Wnt signaling pathway cell migration negative regulation of Wnt signaling pathway positive regulation of cell migration positive regulation of pseudopodium assembly regulation of microtubule-based process positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity regulation of attachment of spindle microtubules to kinetochore regulation of microtubule-based movement protein-containing complex assembly bicellular tight junction assembly negative regulation of canonical Wnt signaling pathway positive regulation of cold-induced thermogenesis negative regulation of cell cycle G1/S phase transition positive regulation of protein localization to centrosome negative regulation of G1/S transition of mitotic cell cycle kidney development hair follicle development metaphase/anaphase transition of mitotic cell cycle establishment or maintenance of cell polarity axonogenesis axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation stem cell population maintenance regulation of cell migration regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis negative regulation of apoptotic process negative regulation of MAPK cascade skin development regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation chromosome organization regulation of cell cycle positive regulation of cell division retina development in camera-type eye negative regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development nitrogen cycle metabolic process response to xenobiotic stimulus pancreas development response to alcohol cellular response to nerve growth factor stimulus
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