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Invitrogen
CD56 Monoclonal Antibody (B488 (123-C3))
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产品信息
MA1-91222
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
B488 (123-C3)
抗原
Membrane preparation of small cell lung carcinoma.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
规格
150 µg
保存条件
4°C, do not freeze
运输条件
Wet ice
产品详细信息
MA1-91222 detects CD56 from human samples.
MA1-91222 has been successfully used in flow cytometry, immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue) and ELISA applications. Suggested positive controls include Tonsil, spleen and thymus.
The MA1-91222 immunogen is membrane preparation of small cell lung carcinoma.
靶标信息
CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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