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Invitrogen
XPA Monoclonal Antibody (12F5)
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产品信息
MA1-91767
应用
建议稀释比
已发表文章
产品规格
已发表种属
Bovine,
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
12F5
抗原
BALB/C mice were injected with recombinant human XPA protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
4°C
运输条件
Wet ice
产品详细信息
MA1-91767 detects XPA from human samples.
MA1-91767 has been successfully used in immunohistochemistry (paraffin tissue), Western blot applications.
The MA1-91767 immunogen is: BALB/C mice were injected with recombinant human XPA protein.
靶标信息
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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