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Invitrogen
Calcium Sensing Receptor Monoclonal Antibody (5C10, ADD)
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FIGURE: 1 / 59
Calcium Sensing Receptor Antibody (MA1-934) in IHC (P)
Immunohistochemistry was performed on normal biopsies of deparaffinized Human kidney tissue. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:100 with a mouse monoclonal ant... View More
Product Details
MA1-934
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5C10, ADD
Immunogen
Synthetic peptide corresponding to residues (214) A D D D Y G R P G I E K F RE E A E E R D I (235) of human calcium sensing receptor.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-934 detects human, bovine, mouse, and rat calcium sensing receptor.
MA1-934 has been successfully used in Western blot, immunohistochemistry, and ELISA procedures. By Western blot, this antibody detects an ~ 150 and 130 kDa proteins from human HEK-293 cells.This antibody has also been used in immunohistochemical on frozen bovine parathyroid gland and rat thyroid gland.
The MA1-934 immunogen is a synthetic peptide corresponding to residues (214) A D D D Y G R P G I E K F RE E A E E R D I (235) of human calcium sensing receptor.
Target Information
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BoPCaR1; Ca sensing receptor; calcium receptor|CaR; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaR; CaSR; CaSR antibody; cation sensing receptor; Extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; PCaR1
Gene Aliases: BoPCaR1; CAR; CASR; EIG8; FHH; FIH; GPRC2A; hCasR; HHC; HHC1; HYPOC1; NSHPT; PCAR1
UniProt ID: (Bovine) P35384, (Human) P41180, (Rat) P48442, (Mouse) Q9QY96
Entrez Gene ID: (Bovine) 281038, (Human) 846, (Rat) 24247, (Mouse) 12374
G-protein coupled receptor activity
calcium ion binding
protein binding
amino acid binding
protein homodimerization activity
integrin binding
protein kinase binding
identical protein binding
ion channel binding
metal ion binding
magnesium ion binding
drug binding
polyamine binding
signal transducer activity
G-protein coupled receptor
ossification
detection of calcium ion
calcium ion transport
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of ATPase activity
vasodilation
calcium ion import
response to ischemia
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
chemosensory behavior
anatomical structure morphogenesis
response to metal ion
positive regulation of insulin secretion
bile acid secretion
cellular response to hepatocyte growth factor stimulus
positive regulation of vasoconstriction
branching morphogenesis of an epithelial tube
positive regulation of positive chemotaxis
response to calcium ion
regulation of calcium ion transport
fat pad development
positive regulation of ERK1 and ERK2 cascade
cellular response to vitamin D
cellular response to glucose stimulus
cellular response to low-density lipoprotein particle stimulus
cellular response to hypoxia
response to fibroblast growth factor
positive regulation of calcium ion import
regulation of presynaptic membrane potential
adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
positive regulation of NLRP3 inflammasome complex assembly
cellular response to peptide
chloride transmembrane transport
apoptotic process
response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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