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Invitrogen
CD56 Monoclonal Antibody (123C3.D5)
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图: 1 / 8
CD56 Antibody (MA5-12685) in ICC/IF
Immunofluorescent analysis of CD56 (green) showing staining in the membrane and secretion of SH-SY5Y cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a CD56 monoclonal antibody (Product # MA5-12685) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the... View More
产品信息
MA5-12685
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse,
Non-human primate
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
123C3.D5
抗原
Membrane preparation of a small cell lung carcinoma
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
保存条件
4°C
运输条件
Wet ice
产品详细信息
MA5-12685 targets CD56 in ICC/IF, FACS, WB and IHC (P) applications and shows reactivity with Human and Rat samples. This antibody is not recommended for U87-MG cells in Western blot applications.
The MA5-12685 immunogen is membrane preparation of a small cell lung carcinoma.
靶标信息
CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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