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Invitrogen
Chromogranin A Monoclonal Antibody (LK2H10)
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FIGURE: 1 / 28
Chromogranin A Antibody (MA5-13096) in ICC/IF
Immunofluorescent analysis of Chromogranin A (green) showing staining in the cytoplasm of SH-SY5Y cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a Chromogranin A monoclonal antibody (Product # MA5-13096) i... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-13096
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
LK2H10
Immunogen
Human pheochromocytoma
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13096 targets Chromogranin A in IHC (P), ICC/IF and WB applications and shows reactivity with Human, Non-human primate, Porcine, Rabbit, and Rat samples.
The MA5-13096 immunogen is human pheochromocytoma.
Target Information
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; cgA; chromofungin; chromogranin A; chromogranin A (parathyroid secretory protein 1); chromogranin A precursor; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; pancreastatin; parathyroid secretory protein 1; pituitary secretory protein I; prohormone; SP-I; unnamed protein product
Gene Aliases: CGA; ChrA; PHE5; PHES
UniProt ID: (Pig) P04404, (Human) P10645, (Mouse) P26339
Entrez Gene ID: (Pig) 397540, (Human) 1113, (Rabbit) 100346049, (Mouse) 12652, (Rat) 24258
positive regulation of protein phosphorylation
regulation of the force of heart contraction
mast cell chemotaxis
protein localization to secretory granule
negative regulation of catecholamine secretion
defense response to bacterium
mast cell degranulation
mast cell activation
positive regulation of vasoconstriction
negative regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
regulation of cytosolic calcium ion concentration
positive regulation of cardiac muscle contraction
positive regulation of cAMP/PKA signal transduction
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
ovulation cycle
mast cell cytokine production
regulation of blood pressure
innate immune response
adenylate cyclase-activating adrenergic receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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