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Invitrogen
Cytokeratin Pan Antibody Cocktail
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图: 1 / 18
Cytokeratin Pan Antibody (MA5-13203) in ICC/IF
Immunofluorescence analysis of Cytokeratin Pan was performed using 70% confluent log phase A-431 cells. The cells were fixed and permeabilized with ice-cold acetone at 4°C for 5 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Cytokeratin Pan Antibody Cocktail (Product # MA5-13203, 5 µg/mL) in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-13203
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Fish,
Guinea pig,
Human,
Mouse,
Pig
宿主/亚型
Mouse
/ IgG, kappa
分类
Cocktail
类型
Antibody
克隆号
PAN-CK
抗原
Human epidermal keratins
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is a broad-spectrum pan-keratin monoclonal antibody cocktail which recognizes keratin 4, 5, 6, 7, 8, 10, 13, 14, 18 and 19. This product can differentiate between epithelial and non-epithelial tumors.
For staining of formalin-fixed tissue,digest sections wtih trypsin at 1 mg/mL in PBS, 10 min at 37°C, or Protease XXV at 1 mg/mL in PBS for 5 min at 37°C.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 39.1; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 19; cytokeratin 5; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6D; Cytokeratin-7; Cytokeratin-8; Cytoskeletal 57 kDa keratin; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermolysis bullosa simplex, Dowling-Meara, Koebner; Epithelial keratin-2e; Hair alpha protein; HMWCK; intermediate filament protein; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K3; K4; K5; K6A; K7; K76; K77; K8; Keratin 1B; keratin 2 epidermis; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; Keratin type II cytoskeletal 5; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; Keratin-7; Keratin-76; Keratin-77; Keratin-8; KRT1B; krt2; krt5; krt7; krt76; mK6-alpha; Pan CK; pan Cytokeratin; pan keratin; pankeratin; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type II cytoskeletal 1b; type II keratin Kb39; type-II intermediate filament protein; Type-II keratin Kb1; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9
基因别名: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 4732484G22Rik; AA960620; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; Card2; CK13; CK18; CK5; CYK18; CYK4; CYK8; D130054E02Rik; D15Wsu77e; EndoA; EndoC; K10; K13; K14; K15; K16; K17; K18; K19; K1C1; K1emb; K2e; K4; K5; K6A; K7; K8; Ker2; Kerd; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; Krt2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; Krt6; KRT6A; KRT6D; KRT7; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; mK1b; mK6[a]; MK6a; PIG46; SCL; Tfip8
structural molecule activity
carbohydrate binding
protein binding
keratin filament binding
scaffold protein binding
structural constituent of cytoskeleton
MHC class II receptor activity
MHC class II protein binding
poly(A) RNA binding
structural constituent of muscle
protein complex binding
molecular_function
protein heterodimerization activity
morphogenesis of an epithelium
signal transduction
positive regulation of cell growth
hair follicle morphogenesis
keratinization
intermediate filament organization
positive regulation of translation
positive regulation of hair follicle development
immune system process
inflammatory response
aging
keratinocyte differentiation
negative regulation of cell migration
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
mitophagy in response to mitochondrial depolarization
epithelial cell differentiation
intermediate filament bundle assembly
cytoskeleton organization
cellular response to calcium ion
cell morphogenesis involved in differentiation
multicellular organism development
tumor necrosis factor-mediated signaling pathway
sarcomere organization
response to hydrostatic pressure
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
Wnt signaling pathway
wound healing
embryo development
negative regulation of epithelial cell proliferation
biological_process
complement activation, lectin pathway
negative regulation of inflammatory response
epidermis development
sebaceous gland development
Notch signaling pathway
Golgi to plasma membrane CFTR protein transport
negative regulation of apoptotic process
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