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Invitrogen

p35 Monoclonal Antibody (B.33.3)

Advanced Verification
1 Published Figure
2 References
View all (8) p35 antibodies

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p35 Monoclonal Antibody (B.33.3)

Product Details

MA5-14834

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50
View 1 publication 1 publication

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Cynomolgus monkey

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

B.33.3

Immunogen

Synthetic peptide from the carboxy terminus of human p35
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

146 µg/mL

Amount

14.6 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10978284

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CDK5 activator 1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; neuronal CDK5 activator; p23; p35; regulatory partner for CDK5 kinase; tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit

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Gene Aliases: CDK5P35; CDK5R; CDK5R1; D11Bwg0379e; NCK5A; p23; p25; p35; p35nck5a

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UniProt ID: (Human) Q15078, (Rat) P61810, (Mouse) P61809

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Entrez Gene ID: (Human) 8851, (Rat) 116671, (Mouse) 12569

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Function(s)
protease binding actin binding protein kinase activity calcium ion binding protein binding kinase activity protein kinase binding protein kinase activator activity ionotropic glutamate receptor binding alpha-tubulin binding protein serine/threonine kinase activator activity cadherin binding beta-tubulin binding actin filament binding cyclin-dependent protein serine/threonine kinase activator activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein kinase 5 activator activity ephrin receptor binding cytoskeletal protein binding kinase activator
Process(es)
regulation of cyclin-dependent protein serine/threonine kinase activity microtubule cytoskeleton organization neuron migration neuron cell-cell adhesion G-protein coupled acetylcholine receptor signaling pathway axon guidance axonal fasciculation brain development regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cerebellum development superior olivary nucleus maturation hippocampus development cerebral cortex radially oriented cell migration layer formation in cerebral cortex neuron differentiation positive regulation of microtubule polymerization neuron projection development regulation of actin cytoskeleton organization ionotropic glutamate receptor signaling pathway positive regulation of neuron apoptotic process positive regulation of MHC class II biosynthetic process regulation of neuron differentiation negative regulation of transcription, DNA-templated ephrin receptor signaling pathway rhythmic process regulation of dendritic spine morphogenesis G1 to G0 transition involved in cell differentiation regulation of microtubule cytoskeleton organization positive regulation of protein targeting to membrane positive regulation of tumor necrosis factor-mediated signaling pathway protein phosphorylation negative regulation of axon extension serine phosphorylation of STAT3 protein positive regulation of protein kinase activity axon extension positive regulation of cell cycle arrest positive regulation of protein serine/threonine kinase activity regulation of cell cycle
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