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Invitrogen
Phospho-(Ser/Thr) ATM + ATR Substrate Monoclonal Antibody (G.770.10)
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产品信息
MA5-14872
产品规格
种属反应
All
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
G.770.10
抗原
Synthetic phospho-ATM/ATR substrate peptides
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
192 µg/mL
规格
19.2 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with corresponding nonphosphorylated sequences or with other phospho-Ser/Thr-containing motifs.
This antibody preferentially binds peptides and proteins that contain phospho-Ser/Thr preceded by Leu or similar hydrophobic amino acids at the -1 position and followed by Gln at the +1 position.
靶标信息
Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1. The essential requirement for the substrates of ATM/ATR is S*/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S*/T*Q are negative determinants for substrate phosphorylation. The complex phenotype of AT cells suggests that it likely has additional substrates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: L(s/t)Q; SQ/TQ
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