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Invitrogen
RSK1/RSK2/RSK3 Monoclonal Antibody (F.940.7)
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FIGURE: 1 / 4
RSK1/RSK2/RSK3 Antibody (MA5-15040) in ICC/IF
Immunofluorescence analysis of RSK1/RSK2/RSK3 was performed using 70% confluent log phase U-87 MG cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with RSK1/RSK2/RSK3 Monoclonal Antibody (F.940.7) (Product # MA5-15040) at 1:100 in 0.1% BSA, incubated at... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15040
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Guinea pig,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
F.940.7
Immunogen
Synthetic peptide corresponding to residues surrounding Asp659 of human p90RSK
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
67 µg/mL
Amount
6.7 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 1; 90 kDa ribosomal protein S6 kinase 2; 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1a; MAP kinase-activated protein kinase 1b; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1a; MAPK-activated protein kinase 1b; MAPK-activated protein kinase 1c; MAPKAP kinase 1a; MAPKAP kinase 1b; MAPKAP kinase 1c; MAPKAPK-1a; MAPKAPK-1c; MAPKAPK1A; p90 rsk; p90-RSK 1; p90-RSK 2; p90-RSK 3; p90RSK1; p90RSK2; p90S6K; pp90RSK1; pp90RSK2; pp90RSK3; Protein-tyrosine kinase Mpk-9; ribosomal protein S6 kinase 2; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-1; Ribosomal protein S6 kinase alpha-2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2; Ribosomal S6 kinase 1; Ribosomal S6 kinase 2; Ribosomal S6 kinase 3; RP11-393H10.3; RSK-1; RSK-2; RSK-3; S6 protein kinase (Rsk-1); S6K-alpha 1; S6K-alpha 2; S6K-alpha-1; S6K-alpha-2; S6K-alpha-3
Gene Aliases: 90kDa; C130006E23; D17Wsu134e; ISPK1; Mapkapk-1a; MAPKAPK-1b; MAPKAPK1A; MAPKAPK1B; MAPKAPK1C; MPK-9; p90-Rsk1; p90rsk; p90Rsk1; p90RSK3; p90S6K; pp90rsk; pp90RSK2; RGD1563860; Rps6ka-rs1; RPS6KA1; RPS6KA2; RPS6KA3; Rsk; Rsk-1; RSK1; RSK2; RSK3; S6K-alpha-1; S6K-alpha3
UniProt ID: (Rat) Q63531, (Mouse) P18653, (Mouse) Q9WUT3, (Mouse) P18654
magnesium ion binding
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
protein serine/threonine/tyrosine kinase activity
ATP binding
transcription factor binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein binding
protein kinase binding
molecular_function
protein modifying enzyme
non-receptor serine/threonine protein kinase
protein phosphorylation
intracellular signal transduction
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hepatic stellate cell activation
regulation of translation
phosphorylation
hepatocyte proliferation
oocyte maturation
brain renin-angiotensin system
heart development
negative regulation of cell proliferation
positive regulation of gene expression
cardiac muscle cell apoptotic process
peptidyl-serine phosphorylation
positive regulation of apoptotic process
negative regulation of cell cycle
negative regulation of meiotic nuclear division
heart contraction
regulation of protein processing
cellular response to carbohydrate stimulus
toll-like receptor signaling pathway
cell cycle
response to lipopolysaccharide
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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