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Invitrogen

MEK1/MEK2 Monoclonal Antibody (J.653.9)

View all (34) MEK1/2 antibodies

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Product Details

MA5-15135

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:25
-

Immunocytochemistry (ICC/IF)

1:25
-

Flow Cytometry (Flow)

1:25
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

J.653.9

Immunogen

Full length MEK1/2 proteins

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 µg/mL

Amount

0.2 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11000214

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; MEK2; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 1; MP2K1; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45

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Gene Aliases: AA589381; MAP2K1; MAP2K2; MAPKK1; MEK1; MEK2; MEKK1; MK2; MKK2; PRKMK1; PRKMK2

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UniProt ID: (Mouse) P31938, (Rat) Q01986, (Rat) P36506, (Mouse) Q63932

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Entrez Gene ID: (Mouse) 26395, (Rat) 170851, (Rat) 58960, (Mouse) 26396

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups Ras GTPase binding protein kinase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity protein N-terminus binding PDZ domain binding protein complex scaffold scaffold protein binding non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade activation of MAPK activity regulation of protein phosphorylation regulation of vascular smooth muscle contraction protein phosphorylation response to oxidative stress cell cycle arrest mitotic nuclear division cell proliferation negative regulation of cell proliferation positive regulation of gene expression phosphorylation neuron differentiation keratinocyte differentiation positive regulation of cell migration melanosome transport regulation of stress-activated MAPK cascade positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion peptidyl-tyrosine dephosphorylation positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of Ras protein signal transduction vesicle transport along microtubule Golgi inheritance response to axon injury regulation of axon regeneration neuron projection morphogenesis cell motility positive regulation of axonogenesis protein heterooligomerization response to glucocorticoid lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence mitophagy in response to mitochondrial depolarization regulation of early endosome to late endosome transport peptidyl-tyrosine phosphorylation intracellular signal transduction peptidyl-serine autophosphorylation positive regulation of cell motility
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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