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Invitrogen

Abl2 Monoclonal Antibody (1H1)

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产品信息

MA5-15586

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫细胞化学 (ICC/IF)

1:200-1:1,000
-

酶联免疫吸附实验 (ELISA)

1:10,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1H1

抗原

Purified recombinant fragment of ABL2 expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

ascites

内含物

0.03% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10977285

产品详细信息

MA5-15586 targets ABL2 in indirect ELISA, IF and WB applications and shows reactivity with Human and mouse samples.

The MA5-15586 immunogen is purified recombinant fragment of ABL2 expressed in E. Coli.

MA5-15586 detects ABL2 which has a predicted molecular weight of approximately 128kDa.

靶标信息

ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; abl2; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; tyrosine kinase ARG; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

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基因别名: AA536808; ABL2; ABLL; ARG

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Entrez Gene ID: (Human) 27, (Mouse) 11352

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功能
magnesium ion binding phosphotyrosine binding actin monomer binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity enzyme binding manganese ion binding actin filament binding nucleotide binding receptor binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
参与通路
signal transduction epidermal growth factor receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration regulation of autophagy positive regulation of neuron projection development peptidyl-tyrosine phosphorylation regulation of endocytosis regulation of cell adhesion regulation of actin cytoskeleton organization cellular response to oxidative stress negative regulation of Rho protein signal transduction exploration behavior protein modification process cellular response to retinoic acid positive regulation of establishment of T cell polarity regulation of cell motility positive regulation of T cell migration protein phosphorylation phagocytosis substrate-dependent cell migration, cell extension actin filament organization cell adhesion learning visual learning positive regulation of phospholipase C activity phosphorylation neuron remodeling cell migration cerebellum morphogenesis negative regulation of cell-cell adhesion actin cytoskeleton organization positive regulation of protein binding cellular protein localization peptidyl-tyrosine autophosphorylation regulation of cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response alpha-beta T cell differentiation platelet-derived growth factor receptor signaling pathway dendrite morphogenesis neuromuscular process controlling balance actin filament bundle assembly positive regulation of oxidoreductase activity Bergmann glial cell differentiation positive regulation of ERK1 and ERK2 cascade dendritic spine maintenance positive regulation of interleukin-2 secretion positive regulation of interferon-gamma secretion regulation of extracellular matrix organization positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process
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