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Invitrogen
Aurora A Monoclonal Antibody (1F8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F8
Immunogen
Purified recombinant fragment of human AURKA expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15803 targets AURKA in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human, Non-human primate, and Rat samples.
The MA5-15803 immunogen is purified recombinant fragment of human AURKA expressed in E. Coli.
MA5-15803 detects AURKA which has a predicted molecular weight of approximately 48kDa.
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AURAK; aurora 2; Aurora A Kinase; aurora-A; aurora-related kinase 1; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; breast tumor-amplified kinase; EC 2.7.11.1; hARK1; ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; protein kinase; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase Ayk1; unnamed protein product
Gene Aliases: AIK; ARK-1; ARK1; AURA; BTAK; PPP1R47; STK15; STK6; STK7
UniProt ID: (Human) O14965
Entrez Gene ID: (Human) 6790, (Rat) 261730
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
protein kinase binding
protein heterodimerization activity
protein serine kinase activity
molecular function activator activity
ubiquitin protein ligase binding
histone kinase activity (H3-S10 specific)
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
chromatin remodeling
protein phosphorylation
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
centrosome cycle
mitotic centrosome separation
response to wounding
anterior/posterior axis specification
negative regulation of gene expression
peptidyl-serine phosphorylation
regulation of protein stability
response to estradiol
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
negative regulation of apoptotic process
positive regulation of translation
positive regulation of mitotic cell cycle
meiotic cell cycle
centrosome localization
cilium disassembly
protein localization to centrosome
positive regulation of mitochondrial fission
liver regeneration
positive regulation of oocyte maturation
positive regulation of meiotic cell cycle process involved in oocyte maturation
neuron projection extension
G2/M transition of mitotic cell cycle
regulation of G2/M transition of mitotic cell cycle
negative regulation of protein binding
regulation of microtubule-based process
cell cycle G2/M phase transition
positive regulation of mitotic nuclear division
regulation of centrosome cycle
protein autophosphorylation
positive regulation of cell cycle process
regulation of signal transduction by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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