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Invitrogen
DLK1 Monoclonal Antibody (3A10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15915
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3A10
Immunogen
Purified recombinant fragment of human DLK1 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15915 targets DLK1 in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15915 immunogen is purified recombinant fragment of human DLK1 expressed in E. Coli. .
MA5-15915 detects DLK1 which has a predicted molecular weight of approximately 41kDa.
Target Information
The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adenoma-associated variant of dlk1 protein; adipocyte differentiation inhibitor protein; alternatively spliced; lacking 219 bp between positions 858 and 859; The 219 bp deletion has been demonstrated to originate by alternative splicing within an exon.; delta-like 1 homolog; dlk; EGF like function; fetal antigen 1; preadipocyte factor 1; PREF; secredeltin; similar to Drosophila; stromal cell derived protein 1; transmembrane domain encoded by 1099-1167.; unnamed protein product
Gene Aliases: Delta1; DLK; DLK-1; DlkI; FA1; Ly107; Peg9; pG2; Pref-1; PREF1; SCP1; ZOG
UniProt ID: (Human) P80370, (Mouse) Q09163
Entrez Gene ID: (Human) 8788, (Mouse) 13386
ossification
osteoblast differentiation
positive regulation of cytokine production
post-embryonic development
regulation of gene expression
cell differentiation
negative regulation of ossification
bone mineralization
multicellular organism growth
negative regulation of cell differentiation
regulation of fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
negative regulation of Notch signaling pathway
positive regulation of bone resorption
regulation of bone remodeling
embryonic skeletal system development
negative regulation of vascular endothelial cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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