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Invitrogen
TERT Monoclonal Antibody (2C4)
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Product Details
MA5-16034
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Cynomolgus monkey,
Human,
Mouse,
Rabbit
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
2C4
Immunogen
Full-length recombinant human Telomerase reverse transcriptase (TERT) from insect cells.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
IgM
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: 293T whole cell lysates, HeLa whole cell lysates, antigen standard for TERT (transient overexpression lysate).
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HEST2; hTERT; Telomerase catalytic subunit; Telomerase reverse transcriptase; telomerase reverse transcriptase beta; Telomerase-associated protein 2; tert {ECO:0000312|RGD:70494}; TP2; unnamed protein product
Gene Aliases: CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TERT; TP2; TR; TRT
UniProt ID: (Human) O14746, (Rat) Q673L6, (Mouse) O70372
Entrez Gene ID: (Human) 7015, (Rat) 301965, (Mouse) 21752
tRNA binding
transcription coactivator binding
DNA binding
telomerase activity
RNA binding
RNA-directed DNA polymerase activity
RNA-directed RNA polymerase activity
protein binding
transferase activity
nucleotidyltransferase activity
DNA polymerase activity
telomeric DNA binding
identical protein binding
protein homodimerization activity
metal ion binding
chaperone binding
telomerase RNA binding
template-free RNA nucleotidyltransferase
telomerase RNA reverse transcriptase activity
DNA metabolism protein
nucleic acid metabolism protein
telomere maintenance via recombination
telomere maintenance
transcription, RNA-templated
RNA-dependent DNA biosynthetic process
protein import into nucleus
telomere maintenance via telomerase
mitochondrion organization
heart development
DNA strand elongation
positive regulation of Wnt signaling pathway
production of siRNA involved in RNA interference
regulation of protein stability
positive regulation of hair cycle
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
positive regulation of glucose import
response to cadmium ion
establishment of protein localization to telomere
cellular response to hypoxia
DNA biosynthetic process
replicative senescence
siRNA transcription
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of transdifferentiation
positive regulation of vascular smooth muscle cell proliferation
positive regulation of protein localization to nucleolus
positive regulation of vascular associated smooth muscle cell migration
negative regulation of endothelial cell apoptotic process
positive regulation of stem cell proliferation
negative regulation of cellular senescence
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
obsolete age-dependent telomere shortening
biological_process
negative regulation of gene expression
telomere formation via telomerase
positive regulation of nitric-oxide synthase activity
negative regulation of production of siRNA involved in RNA interference
RNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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